abstract：:Nociceptive long-term potentiation, a use dependent increase in synaptic efficacy in the dorsal horn of the spinal cord is thought to contribute to the development of persistent pain states. So far, no study has analyzed the effects of high-frequency stimulation (HFS) of afferents from deep tissues (muscle and fascia)...

journal_title：Pain

authors： Schilder A,Magerl W,Hoheisel U,Klein T,Treede RD

更新日期：2016-10-01 00:00:00

abstract：:Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model...

journal_title：Pain

authors： Wodarski R,Delaney A,Ultenius C,Morland R,Andrews N,Baastrup C,Bryden LA,Caspani O,Christoph T,Gardiner NJ,Huang W,Kennedy JD,Koyama S,Li D,Ligocki M,Lindsten A,Machin I,Pekcec A,Robens A,Rotariu SM,VoB S,Segerd

更新日期：2016-10-01 00:00:00

abstract：:Neuroimaging studies of patients with chronic pain have shown that neurotransmitter abnormalities, including increases in glutamate and decreases in GABA, could be responsible for the cortical hyperactivity and hyperalgesia/allodynia observed in some pain conditions. These finding are particularly evident in the insul...

journal_title：Pain

authors： Watson CJ

更新日期：2016-10-01 00:00:00

abstract：:Although conduction failure has been observed in nociceptive C-fibers, little is known regarding its significance or therapeutic potential. In a previous study, we demonstrated that C-fiber conduction failure, which is regarded as an intrinsic self-inhibition mechanism, was reduced in circumstances of painful diabetic...

journal_title：Pain

authors： Wang X,Wang S,Wang W,Duan J,Zhang M,Lv X,Niu C,Tan C,Wu Y,Yang J,Hu S,Xing J

更新日期：2016-10-01 00:00:00

abstract：:Loss of high-voltage-activated (HVA) calcium current (ICa) and gain of low-voltage-activated (LVA) ICa after painful peripheral nerve injury cause elevated excitability in sensory neurons. Nerve injury is also accompanied by increased expression of the extracellular matrix glycoprotein thrombospondin-4 (TSP4), and int...

journal_title：Pain

authors： Pan B,Guo Y,Wu HE,Park J,Trinh VN,Luo ZD,Hogan QH

更新日期：2016-09-01 00:00:00

abstract：:Uncoupling the protein-protein interaction between collapsin response mediator protein 2 (CRMP2) and N-type voltage-gated calcium channel (CaV2.2) with an allosteric CRMP2-derived peptide (CBD3) is antinociceptive in rodent models of inflammatory and neuropathic pain. We investigated the efficacy, duration of action, ...

journal_title：Pain

authors： Xie JY,Chew LA,Yang X,Wang Y,Qu C,Wang Y,Federici LM,Fitz SD,Ripsch MS,Due MR,Moutal A,Khanna M,White FA,Vanderah TW,Johnson PL,Porreca F,Khanna R

更新日期：2016-09-01 00:00:00

abstract：:Pain behaviors are shaped by social demands and learning processes, and chronic pain has been previously suggested to affect their meaning. In this study, we combined functional magnetic resonance imaging with in-scanner video recording during thermal pain stimulations and use multilevel mediation analyses to study th...

journal_title：Pain

authors： Vachon-Presseau E,Roy M,Woo CW,Kunz M,Martel MO,Sullivan MJ,Jackson PL,Wager TD,Rainville P

更新日期：2016-08-01 00:00:00

abstract：:The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast...

journal_title：Pain

authors： Finnerup NB,Haroutounian S,Kamerman P,Baron R,Bennett DLH,Bouhassira D,Cruccu G,Freeman R,Hansson P,Nurmikko T,Raja SN,Rice ASC,Serra J,Smith BH,Treede RD,Jensen TS

更新日期：2016-08-01 00:00:00

abstract：:Musculoskeletal disorders (MSDs) are highly prevalent, painful, and costly disorders. The MSD Cohort was created to characterize variation in pain, comorbidities, treatment, and outcomes among patients with MSD receiving Veterans Health Administration care across demographic groups, geographic regions, and facilities....

journal_title：Pain

authors： Goulet JL,Kerns RD,Bair M,Becker WC,Brennan P,Burgess DJ,Carroll CM,Dobscha S,Driscoll MA,Fenton BT,Fraenkel L,Haskell SG,Heapy AA,Higgins DM,Hoff RA,Hwang U,Justice AC,Piette JD,Sinnott P,Wandner L,Womack JA,Br

更新日期：2016-08-01 00:00:00

abstract：:Pain cannot be directly measured in neonates. Therefore, scores based on indirect behavioural signals such as crying, or physiological signs such as blood pressure, are used to quantify neonatal pain both in clinical practice and in clinical studies. The aim of this study was to determine which of the physiological an...

journal_title：Pain

authors： Välitalo PAJ,van Dijk M,Krekels EHJ,Gibbins S,Simons SHP,Tibboel D,Knibbe CAJ

更新日期：2016-08-01 00:00:00

abstract：:The treatment of neuropathic pain remains a clinical challenge because of its unclear mechanisms and broad clinical morbidity. Matrix metalloproteinase (MMP)-9 and MMP-2 have previously been described as key components in neuropathic pain because of their facilitation of inflammatory cytokine maturation and induction ...

journal_title：Pain

authors： Li J,Xu L,Deng X,Jiang C,Pan C,Chen L,Han Y,Dai W,Hu L,Zhang G,Cheng Z,Liu W

更新日期：2016-08-01 00:00:00

abstract：:Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We evaluated this plasticity by recording responses to mechanical stimuli in silent neurons (nonspontaneously active [NSA]) and neurons showing on...

journal_title：Pain

authors： Medrano MC,Dhanasobhon D,Yalcin I,Schlichter R,Cordero-Erausquin M

更新日期：2016-07-01 00:00:00

abstract：:Sensitization of purinergic P2X3 receptors (P2X3Rs) is a major mechanism contributing to injury-induced exaggerated pain responses. We showed in a previous study that cyclic adenosine monophosphate (cAMP)-dependent guanine nucleotide exchange factor 1 (Epac1) in rat sensory dorsal root ganglia (DRGs) is upregulated af...

journal_title：Pain

authors： Gu Y,Li G,Chen Y,Huang LM

更新日期：2016-07-01 00:00:00

abstract：:Plasticity in inhibitory receptors, neurotransmission, and networks is an important mechanism for nociceptive signal amplification in the spinal dorsal horn. We studied potential changes in GABAergic pharmacology and its underlying mechanisms in hyperalgesic priming, a model of the transition from acute to chronic pai...

journal_title：Pain

authors： Kim JV,Megat S,Moy JK,Asiedu MN,Mejia GL,Vagner J,Price TJ

更新日期：2016-06-01 00:00:00

abstract：:To inform case definition for neck/shoulder pain in epidemiological research, we compared levels of disability, patterns of association, and prognosis for pain that was limited to the neck or shoulders (LNSP) and more generalised musculoskeletal pain that involved the neck or shoulder(s) (GPNS). Baseline data on muscu...

journal_title：Pain

authors： Sarquis LMM,Coggon D,Ntani G,Walker-Bone K,Palmer KT,Felli VE,Harari R,Barrero LH,Felknor SA,Gimeno D,Cattrell A,Vargas-Prada S,Bonzini M,Solidaki E,Merisalu E,Habib RR,Sadeghian F,Kadir MM,Warnakulasuriya SSP,Matsu

更新日期：2016-05-01 00:00:00

abstract：:Clinical trial participants often require additional instruction to prevent idiosyncratic interpretations regarding completion of patient-reported outcomes. The Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION) public-private partnership developed a tr...

journal_title：Pain

authors： Smith SM,Amtmann D,Askew RL,Gewandter JS,Hunsinger M,Jensen MP,McDermott MP,Patel KV,Williams M,Bacci ED,Burke LB,Chambers CT,Cooper SA,Cowan P,Desjardins P,Etropolski M,Farrar JT,Gilron I,Huang IZ,Katz M,Kerns RD

更新日期：2016-05-01 00:00:00

abstract：:Disabling neuropathic pain (NeuP) is a common sequel of diabetic peripheral neuropathy (DPN). We aimed to characterise the sensory phenotype of patients with and without NeuP, assess screening tools for NeuP, and relate DPN severity to NeuP. The Pain in Neuropathy Study (PiNS) is an observational cross-sectional multi...

journal_title：Pain

authors： Themistocleous AC,Ramirez JD,Shillo PR,Lees JG,Selvarajah D,Orengo C,Tesfaye S,Rice ASC,Bennett DLH

更新日期：2016-05-01 00:00:00

abstract：:Colonoscopy is an invaluable tool for the screening and diagnosis of many colonic diseases. For most colonoscopies, moderate sedation is used during the procedure. However, insufflation of the colon produces a nociceptive stimulus that is usually accompanied by facial grimacing/groaning while under sedation. The objec...

journal_title：Pain

authors： Becerra L,Aasted CM,Boas DA,George E,Yücel MA,Kussman BD,Kelsey P,Borsook D

更新日期：2016-04-01 00:00:00

abstract：:Below-level central neuropathic pain (CNP) affects a large proportion of spinal cord injured individuals. To better define the dynamic changes of the spinal cord neural network contributing to the development of CNP after spinal cord injury (SCI), we characterized the morphological and behavioral correlates of CNP in ...

journal_title：Pain

authors： Nees TA,Tappe-Theodor A,Sliwinski C,Motsch M,Rupp R,Kuner R,Weidner N,Blesch A

更新日期：2016-03-01 00:00:00

abstract：:Quantitative sensory testing (QST) in accordance with the DFNS (German Research Network on Neuropathic Pain) protocol assesses the function of afferent nerve fibers on the basis of 13 parameters. Within the consortia IMI (Innovative Medicines Initiative) Europain and Neuropain, QST results from pain research units exp...

journal_title：Pain

authors： Vollert J,Attal N,Baron R,Freynhagen R,Haanpää M,Hansson P,Jensen TS,Rice ASC,Segerdahl M,Serra J,Sindrup SH,Tölle TR,Treede RD,Maier C

更新日期：2016-03-01 00:00:00

abstract：:The treatment of neuropathic pain by neuromodulation is an objective for more than 40 years in modern clinical practice. With respect to spinal cord and deep brain structures, the cerebral cortex is the most recently evaluated target of invasive neuromodulation therapy for pain. In the early 90s, the first successes o...

journal_title：Pain

authors： Lefaucheur JP

更新日期：2016-02-01 00:00:00

abstract：:The information from nociceptors is processed in the dorsal horn of the spinal cord by complex circuits involving excitatory and inhibitory interneurons. It is well documented that GluN2B and ERK1/2 phosphorylation contributes to central sensitization. Striatal-enriched protein tyrosine phosphatase (STEP) dephosphoryl...

journal_title：Pain

authors： Azkona G,Saavedra A,Aira Z,Aluja D,Xifró X,Baguley T,Alberch J,Ellman JA,Lombroso PJ,Azkue JJ,Pérez-Navarro E

更新日期：2016-02-01 00:00:00

abstract：:With increasing concerns about the potential harm of long-term opioid therapy, there is a need for the development and implementation of alternative treatment strategies for patients with chronic pain who have been using opioids for a prolonged period of time. Based on the findings from a recent qualitative investigat...

journal_title：Pain

authors： Andrews NE,Strong J,Meredith PJ,Fleming JA

更新日期：2016-02-01 00:00:00

abstract：:Percentage of pain intensity difference (PercentPID) is a recognized way of evaluating pain relief with an 11-point numerical rating scale (NRS) but is not without flaws. A new metric, the slope of relative pain intensity difference (SlopePID), which consists in dividing PercentPID by the time between 2 pain measureme...

journal_title：Pain

authors： Chauny JM,Paquet J,Lavigne G,Marquis M,Daoust R

更新日期：2016-02-01 00:00:00

abstract：:The field of pediatric pain research began in the mid-1970s and has undergone significant growth and development in recent years as evidenced by the variety of books, conferences, and journals on the topic and also the number of disciplines engaged in work in this area. Using categorical and bibliometric meta-trend an...

journal_title：Pain

authors： Caes L,Boerner KE,Chambers CT,Campbell-Yeo M,Stinson J,Birnie KA,Parker JA,Huguet A,Jordan A,MacLaren Chorney J,Schinkel M,Dol J

更新日期：2016-02-01 00:00:00

abstract：:Internet-delivered interventions are emerging as a strategy to address barriers to care for individuals with chronic pain. This is the first large multicenter randomized controlled trial of Internet-delivered cognitive-behavioral therapy (CBT) for pediatric chronic pain. Participants included were 273 adolescents (205...

journal_title：Pain

authors： Palermo TM,Law EF,Fales J,Bromberg MH,Jessen-Fiddick T,Tai G

更新日期：2016-01-01 00:00:00

abstract：:Recent studies reported the translocator protein (TSPO) to play critical roles in several kinds of neurological diseases including the inflammatory and neuropathic pain. However, the precise mechanism remains unclear. This study was undertaken to explore the distribution and possible mechanism of spinal TSPO against c...

journal_title：Pain

authors： Liu X,Liu H,Xu S,Tang Z,Xia W,Cheng Z,Li W,Jin Y

更新日期：2016-01-01 00:00:00

abstract：:We propose a blade as a noninjurious nociceptive stimulus modeling sharp mechanical pain and yielding acute pain and hyperalgesia responses with closer proximity to incision-induced pain/hyperalgesia than punctate or blunt pressure mechanical pain models. Twenty-six healthy men and women were investigated to compare a...

journal_title：Pain

authors： Shabes P,Schloss N,Magerl W,Schmahl C,Treede RD,Baumgärtner U

更新日期：2016-01-01 00:00:00

abstract：:Regular physical activity in healthy individuals prevents development of chronic musculoskeletal pain; however, the mechanisms underlying this exercise-induced analgesia are not well understood. Interleukin-10 (IL-10), an antiinflammatory cytokine that can reduce nociceptor sensitization, increases during regular phys...

journal_title：Pain

authors： Leung A,Gregory NS,Allen LH,Sluka KA

更新日期：2016-01-01 00:00:00

abstract：:Patients with neuropathic pain commonly present with spontaneous pain, in addition to allodynia and hyperalgesia. Although evoked responses in neuropathic pain models are well characterized, determining the presence of spontaneous pain is more challenging. We determined whether the chronic constriction injury (CCI) mo...

journal_title：Pain

authors： Dalm BD,Reddy CG,Howard MA,Kang S,Brennan TJ

更新日期：2015-12-01 00:00:00

abstract：:We evaluated the construct validity (including responsiveness), reliability, and feasibility of the Pain Squad multidimensional smartphone-based pain assessment application (app) in children and adolescents with cancer, using 2 descriptive studies with repeated measures. Participants (8-18 years) undergoing cancer tre...

journal_title：Pain

authors： Stinson JN,Jibb LA,Nguyen C,Nathan PC,Maloney AM,Dupuis LL,Gerstle JT,Hopyan S,Alman BA,Strahlendorf C,Portwine C,Johnston DL

更新日期：2015-12-01 00:00:00

abstract：:Patients with schizophrenia report reduced pain sensitivity in clinical studies, but experimental studies are required to establish pain sensitivity as a potential endophenotype. We conducted a systematic review of electronic databases from database inception until April 15, 2015, including experimental studies invest...

journal_title：Pain

authors： Stubbs B,Thompson T,Acaster S,Vancampfort D,Gaughran F,Correll CU

更新日期：2015-11-01 00:00:00

abstract：:For genetic research to contribute more fully to furthering our knowledge of neuropathic pain, we require an agreed, valid, and feasible approach to phenotyping, to allow collaboration and replication in samples of sufficient size. Results from genetic studies on neuropathic pain have been inconsistent and have met wi...

journal_title：Pain

authors： van Hecke O,Kamerman PR,Attal N,Baron R,Bjornsdottir G,Bennett DLH,Bennett MI,Bouhassira D,Diatchenko L,Freeman R,Freynhagen R,Haanpää M,Jensen TS,Raja SN,Rice ASC,Seltzer Z,Thorgeirsson TE,Yarnitsky D,Smith BH

更新日期：2015-11-01 00:00:00

abstract：:Tibia fracture induces exaggerated substance P (SP) and calcitonin gene-related peptide (CGRP) signaling and neuropeptide-dependent nociceptive and inflammatory changes in the hind limbs of rats similar to those seen in complex regional pain syndrome. Inflammatory changes in the spinal cord contribute to nociceptive s...

journal_title：Pain

authors： Shi X,Guo TZ,Wei T,Li WW,Clark DJ,Kingery WS

更新日期：2015-10-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNICs) utilize descending inhibitory controls through poorly understood brain stem pathways. The human counterpart, conditioned pain modulation, is reduced in patients with neuropathy aligned with animal data showing a loss of descending inhibitory noradrenaline controls together w...

journal_title：Pain

authors： Bannister K,Patel R,Goncalves L,Townson L,Dickenson AH

更新日期：2015-09-01 00:00:00

abstract：:Activated mammalian target of rapamycin (P-mTOR) has been shown to maintain the sensitivity of subsets of small-diameter primary afferent A-nociceptors. Local or systemic inhibition of the mTOR complex 1 (mTORC1) pathway reduced punctate mechanical and cold sensitivity in neuropathic pain and therefore offered a new a...

journal_title：Pain

authors： Obara I,Medrano MC,Signoret-Genest J,Jiménez-Díaz L,Géranton SM,Hunt SP

更新日期：2015-08-01 00:00:00

abstract：:According to fear-avoidance models, a catastrophic interpretation of a painful experience may give rise to pain-related fear and avoidance, leading to the development and maintenance of chronic pain problems in the long term. However, little is known about how exactly motivation and goal prioritization play a role in ...

journal_title：Pain

authors： Claes N,Crombez G,Vlaeyen JWS

更新日期：2015-08-01 00:00:00

abstract：:Nonopioid agents, such as nonsteroidal anti-inflammatory drugs (NSAIDs), are the most commonly used class of analgesics. Increasing evidence suggests that cyclooxygenase (COX) inhibition at both peripheral and central sites can contribute to the antihyperalgesic effects of NSAIDs, with the predominant clinical effect ...

journal_title：Pain

authors： Hodkinson DJ,Khawaja N,O'Daly O,Thacker MA,Zelaya FO,Wooldridge CL,Renton TF,Williams SCR,Howard MA

更新日期：2015-07-01 00:00:00

abstract：:Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for oste...

journal_title：Pain

authors： Wylde V,Lenguerrand E,Gooberman-Hill R,Beswick AD,Marques E,Noble S,Horwood J,Pyke M,Dieppe P,Blom AW

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the effects of a single administration of 6-(4-methoxyphenyl)-5-methyl-3-pyridinyl-4-isoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP), a negative allosteric modulator (NAM) of metabotropic glutamate receptor 7 (mGluR7), on pain and on affective and cognitive behavior in neuropathic mice. The activity ...

journal_title：Pain

authors： Palazzo E,Romano R,Luongo L,Boccella S,De Gregorio D,Giordano ME,Rossi F,Marabese I,Scafuro MA,de Novellis V,Maione S

更新日期：2015-06-01 00:00:00